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Exceptional changesin prognostic, diagnostics, and subsequently Medicaid/ Medicare or’ cancer patients have potentially resulted in an excessive accelerated mortality rate, however. Besides, a significant increase in cancer patients' morbidity and mortalitybecame a fact, in this postcovid- 19 periods (www.ourworldindata.com, Cancer Facts & Figures 2024). [1-4] Understandlng different hemato-oncologic mechanisms of either unilateral or -bidirectional interactions between different angles of the death trianglemight play a pivotal role as a lifesaving novel tool to prevent accelerated excessivemortality rates, in these post covid—19 war periods, which I invented before pandeinic attacks since 2018.[3] Remarkable acceleratedexcessive mortality rates among chronic patients i.e. cancer patients that disastrously increased remains a mysterious black box mechanism, in these post-COVID-19 periods. Multiple studies,in the last years, have shed light on the effects of defective-/ bias-based Pro- and Diagnostics. (l-b) There are different blood cells that could play a role in increasing mortality rates INovember 2024). These include increased hypotheiically i.e. myocarditis, cancerogenous reactions of bone marrow, chronic neuromuscular pain, difl’erent disabilities that can accelerate either epileptic and seizureattacks , blackouts, brain fog, and tatigue, or much worse even potential activationof death receptors.[2-5] Which mechanism(s) of action induce such systemicdisorders and/or accelerate cancerogenous indications with(out)cardiovascular disorders are not completelyelucidated yet. Dift“erent questions still remain over excessive mortality rates in the last [4-5] years between cancer patients who normally before 2016 survived longer than 2-3 years after the same cancerogenous processes, diagnosed and got the same treatments. Why in the last 4-5 years,mortality rates among chronic cancer patients converted to a accelerated death receptors activities is not completely elucidated, as well (www.ourworldindata.com)‘? There are different speculations and hypothesis which might help open modern view and new angle of death triangle machinery, to prolong at least 5-years survivalof cancer patients, however, [3] Furthermore, the speed of different pathological processes and rapid pathological changes,between chronic patients can initiate susceptibility to getting earlierinfection which also the mechanism of action(s) is(are) remainingunknown aspects, in this post-COVID-19 period (November 2024). In the last 4-5 years, compared to females, males almost two times more died (www.ourwor1dindata.com, www.WHO.org). Indicating that somethingis significantly wrong with Pro- and Diagnostics and subsequently Medicare and Medicare of males, which shouldbe completely investigated and the main reason being elucidated. Different published statistical data over the cancer facts andfigures in 2024, compared to 2015,indicates that in the last 4-5 years a rare phenomenal (un)known(mu1ti)factorial processes are affecting accelerated morbidity and mortality rates, based on physical spatial and temporal variants, on the other hand. Another interesting aspect to unravel is whether chronic patients in the last 4-5 years, indicated how novel coronavirus variants (in)directly interact with novel COVID-19mutants, which was alsonot entirely their interaction have been not completely elucidated yet. There are different hypotheses among scientists, which have caused a kind of confusion between readers, globally. Hogan RE et at. 2020 postulated that overall findings indicate seizures andepilepsy are rare, especially in mild COVJD-19cases, but may occur in more severe cases later in the disease course. Caregivers should be vigilant in assessing for possible seizures, especially in patients with systemic effects of severe COVID-19 infections. [6] Hassan L et at. 2023 presented a rare case report that highlighted a unique case ot brain fog in a COVID-19 patient, suggesting COVID-19's neurotrophic nature. The COVID-19 mutant could be associated with a long-COVID-19 syndrome that presentswith cognitive decline and fatigue [7] whlch could be seen also in chronic cancer patients, atf”ected either physiologlc or pathologically. There are (un)knownreasons to mention, that in the last 4-5 years, suddenly chronic cancer patientsdied in an accelerated manner.[1-5] The sincerequestion remains that “which aspectof underlying morbidity-mortality mechan1srn(s) is(are) not elucidated completely' And why not There are different hypotheses/ speculations, and model systems proposedthat have predicted Why? How?What? Which action mechanism might play a significant role in ind ucing accelerated activation of death receptors, causing excessive morbidity and mortality rates, however.[1-5] Brown E.E. et a1. 2020 postulated that pandemic attacks of’ COVID-19 mutants and associated restrictions were causing global morbidity and mortality, straining health systems, and disrupting societies, putting different individuals affected with Alzheimer's disease and related dementias at risk of significant harm, however. [5] Paolini A. et at. 2021 in their review postulated that cell death mechanisms are crucial to maintaining an appropriate environment for the functionality of healthy cells. [8] Dit’t’erent hematologic and lymphatic processesplay a pivotal role in cancer patients'diagnostic results. For example, lymphopenia and monocytopenia are considered an important contributor{s) to immunopathogenesis,but the exact action mechanism[s] between cancer patients remains unknow n. In all kindsot’ cancers, dysregulation ot’ oncogenic and pathologic changescould be presentbut when and how certain molecularand inter/intracellular factors panicipate in the cancerogenic mechanismswhich directly cause an accelerated death receptor activation are not elucidated completely. [1-13] Besides, it is noteworthy that every study done failed to assess a proof-of-principle mechanism, or more in detail, highlightthe abovementioned questionsand their relevant answersto cancers scientific community. On the other hand, because of (un)known limitations, the most studies focused only in a certain aspect of cancerogenous-known and old-fashioned knowledge, with a fixed rnindsets (Elephant —in-room- discussion). Of course, to name some speculative causes for example1. some old-fashioned restrictions could be seen as the main cause of such delay in oft’ering logicalanswers, however, 2. Economic-Based Goals (EBGs) [1,2] versus the Affordable Care Act (ACA), although, the ACA had showed significant improved access to Medicare/Medicaid, resulting in better insurance coverage and reduced disparities, in the last decade [6-13]. The take home message 1s restricted-old —fashloned views and algorithms dominating Medicareand Medicaid of cancer patients, in the last 4-5 years, Post Covid-19 war era. Different controversial study results have been published are indicating an accelerated excessive morbidity and mortality rates among cancer patients, however.The exact mechanism(s) is not completel elucidated and because of remarkable coverups of discoverysciences One is observing that to preventaccelerated mortality rates either an evolution or Scientific revolution needed soon.

No conflict of interest reported, of any kind.