ClinicShort Communication | DOI: https://doi.org/10.31579/ 2834-5061/15
Chronotherapies and leiomyomas.
- H. D. Solomons *
P.O.Box 64203, Highlands North. 2037
*Corresponding Author: H.D. Solomons, (2024), Chromothripsis and leiomyomas., Clinical Oncology Case Reports, 3(2); DOI: 10.31579/ 2834-5061/15
Citation: H.D. Solomons, (2024), Chromothripsis and leiomyomas., Clinical Oncology Case Reports, 3(2); DOI: 10.31579/ 2834-5061/15
Copyright: © 2024, H.D. Solomons. This is an open-access article distributed under the terms of The Creative Commons. Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 02 February 2024 | Accepted: 05 March 2024 | Published: 25 March 2024
Keywords: HMGA2; leiomyomas; Chromothripsis
Abstract
Data provide evidence of a common origin for a subset of physically distinct leiomyoma nodules on patients.
This finding may explain in part the frequent occurrence of multiple synchronous leiomyomas, and is in line with findings in some early reports karyotyping.
Introduction
Data provide evidence of a common origin for a subset of physically distinct leiomyoma nodules on patients.
This finding may explain in part the frequent occurrence of multiple synchronous leiomyomas, and is in line with findings in some early reports karyotyping.
Two tumours in one patient, two tumours in a second patient, and five tumours in a third patient were shown to have a common clonal karyotyping.
All nine tumours represented the leiomyoma subclass that overexpresses HMGA2.
We observed CCRs resembling chromothripsis in many of the examined lesions.
Such arrangements are a major cause of chromosomal aberrations in leiomyomas and thus an important generator of tumorigenic changes in these lesions.
Until we know more about the mechanisms underlying CCRs, it is not possible to say with certainty whether the CCRs with low number of breakpoints represent the products of chromothripsis or arise through a different mechanism.
We have therefore used the term “chronotherapies “to describe events resulting in more than 20 intrachromosal breakpoints.
Chromothripsis events are not rare in leiomyoma precursor cells as the vast majority of events are not expected to produce targeted changes.
