Curcumin is a chemical produced from turmeric; a plant known for its medicinal use. It is an effective agent for the treatment of several skin conditions. It has been exposed to a variety of antimicrobial investigations due to no side effects and extensive traditional uses. It exhibits many pharmacological activities such as anti-bacterial, anti-inflammatory, anti-cancer, anti-Alzheimer, anti-fungal, anti-viral, antioxidant, and anti-ulcer activity. The likely-looking results for antimicrobial activity of curcumin made it a promising candidate to increase the inhibitory effect of existing antimicrobial agents through synergism. This review goal is to summarize previous studies of curcumin towards its application in future studies as a natural antimicrobial agent.

Curcumin is one of the potent, non-irritating, non-allergenic, and major bioactive component present in turmeric. It is a member of the ginger family, Zingiberaceae. It is also called diferuloylmethane, a bright yellow chemical which is a main natural polyphenol found in the rhizome of Curcuma longa (turmeric). The major issues of curcumin are: it has low absorption and poor bioavailability. [1] Curcuma longa rhizome has been used as an insect repellent and antimicrobial agent. The antimicrobial agent is suitable for textile materials. To develop antimicrobial skin gels and emulsions with improved skin protection and wound dressing properties, a mixture of curcumin with other microbial agents isused. [2]
IUPACname:(1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5- dione)
Formula: C21H20O6
Molar mass: 368.38 g/mol
Appearance: Bright yellow-orange powder
Melting point: 183 °C
Boiling point: 591.4 °C
Solubility: Insoluble in water and ether, but soluble in ethanol, dimethyl sulfoxide, and acetone.
2) Antibacterial Activity
It has been proved that curcumin owns the activity against Helicobacter pylori. The two inflammatory molecules, that are present in H. pylori are metalloproteinase 9(MMP9) and Matrix metalloproteinase 3(MMP3). Curcumin controls the expression of both the MMP3 and MMP9, making it effective against H. pylori. [3]
Curcumin is also studied to be a potential chemopreventive candidate against H. pylori-related gastric carcinogenesis. Curcumin also suppresses V. vulnificus infection. Itdefends host cells from V. vulnificus cytotoxicity and infection. Curcumin will suppress both cell death and induction of the pro-inflammatory response caused by bacterial infection. curcumin exhibit various activities on both eukaryotic cells and V. vulnificus. Curcumin partially suppresses V. vulnificus growth, which probably results in defects seen in adhesion, cytotoxicity, motility, and other virulence-related factors of the pathogen. [4]
Nanoparticles and microemulsion swhichare prepared with curcumin are known for their antimicrobial activity. Curcumin-loaded myristic acid microemulsion which is a formulated curcumin microemulsion is used to suppress Staphylococcus epidermidis, that is mainly responsible for Health-care associated infections. [6] It was also demonstrated that curcumin nanoparticles inhibits the growth of Staphylococcus aureus, Escherichia coli, Pseudomonasaeruginosa, Bacillus subtilis due to its antibacterial activity and it also inhibits Penicillium notatum and Aspergillus niger due to its antifungal activity. [5]
Curcumin microcapsule with more solubility is suitable as a preservative and colorant in the food industry and it shows potent antimicrobial effect against food-borne pathogens including E. coli, Staph. aureus, B. subtilis, B. cereus, Penicillium notatum, Yersinia enterocolitica, and Saccharomyces cerevisiae with MIC values ranging from 15.7 to 250 

Curcumin is popular due to its less toxic effect and has no side effects. It plays an important role in preventingmicrobial diseases. so, it is used as an antibacterial agent, antiviral agent, andantifungal agent. It also reduces wound healing time for skin-related issues.