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Prognosis Of Invasive Micropapillary Carcinoma of The Breast Analyzed by Using the Seer Database

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Research Article | DOI: https://doi.org/10.31579/2835-8090/001

Prognosis Of Invasive Micropapillary Carcinoma of The Breast Analyzed by Using the Seer Database

  • Lang Qin 1
  • Chuanbo Xie 2
  • Kaitao Yuan 3
  • Tiantian Zhen 4
  • Ying Lin 1*
  • Nan Shao 1*

1 Breast Disease Center, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan 2nd Road, Guangzhou 510080, China

2 Cancer Prevention Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510080, China

3 Center of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan 2nd road, Guangzhou 510080, China

4 Department of Pathology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China.

*Corresponding Author: Ying Lin and Nan Shao. Breast Disease Center, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan 2nd Road, Guangzhou 510080, China

Citation: Chuanbo Xie, Kaitao Yuan, Tiantian Zhen, Ying Lin, Nan Shao. (2022). Prognosis Of Invasive Micropapillary Carcinoma of The Breast Analyzed by Using the Seer Databases, Journal of Clinical Chemistry, 1(1) DOI: 10.31579/2835-8090/001.

Copyright: © 2022 Ying Lin, Nan Shao. This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Received: 06 September 2022 | Accepted: 16 September 2022 | Published: 19 September 2022

Keywords: IMPC; IDC; breast cancer; survival; prognosis

Abstract

Background: Invasive micropapillary carcinoma (IMPC) is a rare type of breast cancer with high frequency of regional lymph node metastasis. However, the prognosis of IMPC has remained controversial for decades. We aimed to compare the differences of prognosis between IMPC and Invasive ductal carcinoma(IDC) of the breast by utilizing Surveillance, Epidemiology, and End Results (SEER) database.

Material and Methods: Patients diagnosed with IMPC and IDC between 1 January 2010 and 31 December 2016 from the SEER database were retrieved. Propensity score matching was used to match the two groups at a 1:1 ratio. Breast cancer-specific survival (BCSS) and overall survival (OS) rates were compared between IMPC and IDC using Kaplan-Meier estimates, Log-rank tests, univariate and multivariate Cox proportional hazard models. Stratification analyses on breast subtype were also performed.

Results: A total of 921 patients with IMPC and 173, 621 patients with IDC were included in the present retrospective study. IMPC had more regional node metastasis than IDC (48.97% vs. 31.41%, p<0.05). IMPC had a better prognosis than IDC as shown by both the BCSS (p<0.01) and OS (p=0.03) but shared the same prognosis after PSM. IMPC had a better OS (p=0.04) and less distant metastasis (p=0.04) in the HR+/HER2- breast subtype than IDC. 

Conclusion: IMPC had more axillary lymph nodes metastasis than IDC. Despite aggressive regional invasion, IMPC had a similar outcome compared with IDC in the BCSS and OS after PSM. Furthermore, IMPC had a better overall survival rate and less distant metastasis than IDC in the HR+/HER2- group.

References

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