Liver afflictions are a primary worldwide strength concern, contributing considerably to depression and mortality. These afflictions, containing hepatitis, non-alcoholic fatty liver affliction (NAFLD), cirrhosis, and hepatocellular malignant growth, are often caused by circulating quickly infections, alcohol addiction, weak nutrition, corpulence, and material poisons. Conventional therapies are alive for affliction management, still they frequently come with reactions and restricted long-term influence. Consequently, nutraceuticals have acquired attention as hopeful completing, and supportive powers in liver affliction management on account of their organic inception, favorable security sketch, and multifaceted methods of operation. Nutraceuticals, which are bioactive compounds arising from feed and plant sources, contain polyphenols, flavonoids, silymarin, curcumin, glycyrrhizin, and end-3 fatty acids. These meanings exhibit effective antioxidant, anti-instigative, antifibrotic, and hepatoprotective characteristics. Their ability to adjust oxidative stress, restrict fibrogenesis, organize lipid metabolism, and better liver something which incites activity levels makes bureaucracy valuable in the stop and treatment of differing liver environments. Evidence from clinical and preclinical studies supports their function in lowering liver fat accumulation, restricting ailment progression, and reconstructing liver function. This review investigate the potential part of key nutraceuticals in managing liver afflictions, outlining their methods of action, security descriptions, and therapeutic pertinence. As liver ailments continue to pose meaningful community health challenges, nutraceuticals offer a supportive and deterrent approach alongside normal treatments. However, more exact dispassionate studies are needed to ratify optimum dosages, correct bioavailability, and assess enduring productiveness.

Liver afflictions represent a meaningful all-encompassing health challenge, leading to nearly two million passing occurring worldwide [1]. These afflictions encompass an expansive range of environments, including aggressive hepatitis, alcoholic liver ailment (ALD), non-alcoholic fatty liver ailment (NAFLD), cirrhosis, and hepatocellular abnormal growth in animate being (HCC), many of which are incessant and growing in nature [2,3]. Factors to a degree obesity, motionless behaviors, poor digestive dresses, environmental poisons, and overdone alcohol devouring are major subscribers to hepatic dysfunction [4]. Despite progress in pharmacotherapy, the management of liver ailments remains suboptimal on account of restricted treatment alternatives, unfavorable drug reactions, and extreme costs [5,6]. In light of this, the role of completing and alternative medicine—particularly nutraceuticals—has collected increasing consideration in recent years [7]. Nutraceuticals are bioactive compounds that come from drink sources, that provide energy benefits further basic food, containing disease stop and healing effects [8]. These powers are known for their antioxidant, antagonistic-angering, antifibrotic, immunomodulatory, and hepatoprotective properties [9,10]. Prominent nutraceuticals intentional for liver afflictions include silymarin from milk prickle, curcumin from turmeric, glycyrrhizin from licorice root, resveratrol from crop, and omega-3 greasy acids from bait oils [11–13]. These agents have proved promising belongings in lowering liver enzyme levels, blocking lipid aggregation, enhancing mitochondrial function, and restricting fibrosis in two together clinical and preclinical studies [14]. However, despite these encouraging verdicts, further randomized regulated trials and patterned drug protocols are essential to reinforce their efficacy and security in the dispassionate management of liver ailments [15].

A narrative review method was selected to evaluate the role of nutraceuticals in the stop and situation of liver afflictions. Relevant research was garnered from databases containing PubMed, Scopus, ScienceDirect, and Google Scholar, using keywords to a degree “nutraceuticals,” “liver ailments,” “hepatoprotection,” “silymarin,” “curcumin,” and “NAFLD.” Peer-inspected items written between 2000 and 2024 were contained. Both preclinical and dispassionate studies were deliberate, while studies in non-English dialects and those deficient scientific strictness were expelled. The focus act nutraceuticals accompanying manifested antioxidant, antagonistic-inflammatory, antifibrotic, and hepatoprotective features.

A total of 58 studies were originally labeled, of which 32 joined the inclusion tests. Analysis disclosed that various nutraceuticals revealed hepatoprotective endeavors in animal models and human matters. Silymarin demonstrated a decline in liver catalyst levels (ALT, AST) and upgraded histological liver gravestones in victims with never-ending liver disease. Curcumin has shown antagonistic-angering effects in NAFLD by downregulating NF-κB indicating. Omega-3 greasy acids upgraded hepatic steatosis and insulin sympathy in NAFLD subjects. Glycyrrhizin and resveratrol still showed potential in lowering liver fibrosis and oxidative stress in miscellaneous models. However, skilled was instability in quantity, duration, and form of presidency across studies.

The judgments imply that nutraceuticals can present an image of persuasive something that incites activity in the management of liver disorders. Silymarin’s antioxidative and sheet-fixing conduct help fix hepatic function, while curcumin’s antagonistic-inflammatory belongings weaken hepatocyte damage. Omega-3 greasy acids help the decline of hepatic lipid accumulation, which is exceptionally appropriate in metabolic liver ailments in the way that NAFLD [1–3]. Resveratrol and glycyrrhizin too exhibit antifibrotic properties, signifying potential in state-of-the-art liver fibrosis and cirrhosis administration [4,5]. Despite hopeful consequences, the clinical use of nutraceuticals remnants restricted on account of lacking big randomized reserved trials. Most existent studies are limited in sample amount and various in design. Moreover, the bioavailability of certain compounds, such as curcumin, the debris an important disadvantage [6]. There is further a lack of supervisory oversight in nutraceutical uniformity, that can impact thickness and healing consequences [7].

Nutraceuticals show a promising completing approach in liver ailment and the situation on account of their anti-angering, antioxidant, and hepatoprotective possessions. Key compounds like silymarin, curcumin, glycyrrhizin, and end-3 oily acids have proved potential benefits in two together preclinical and clinical backgrounds. However, further research is needed to decide patterned dosages, correct bioavailability, and evaluate general productiveness and security. Integrating nutraceuticals into liver ailment administration protocols manages embellished patient consequences when secondhand alongside unoriginal analyses.

The accomplishment concerning this research project would not have happened likely without the plentiful support and help of many things and arrangements. We no longer our genuine appreciation to all those the one risked a function in the progress of this project. 

I have no economic or added individual interests, straightforwardly or obliquely, in some matter that conceivably influence or bias my trustworthiness as a journalist concerning this manuscript.

The authors declare that they have no conflicts of interest.

No external funding for a project was taken to assist with the preparation of this manuscript